According to the specialties and laws of pharmacy industry, the idea and corresponding measures on the construction of productive practice-base for the higher vocational education of bio-pharmacy were researched and discussed in this paper. We also discussed the reformation of the higher vocational education and talent-cultivation mode with wok-integrated learning concerned with the practice-base. The college-leading construction and running mode is effective which was made for the practicing and innovative abilities cultivation of students and the skillful-talent cultivation.