EV71感染抗病毒药物及疫苗研究进展

Developments towards antiviral agents and vaccine against enterovirus 71

摘要:

手足口病在世界多个地区, 尤其是亚洲爆发并流行, 且其感染率和死亡率逐年增高, 危害十分严重。肠道病毒71 (Enterovirus 71, EV71)是手足口病(Hand, foot, and mouth disease, HFMD)的主要病原体, 以感染婴幼儿为主, 其感染常伴随神经系统并发症, 严重可导致儿童死亡。近年来, 分子生物学和抗病毒研究方面取得的进展为EV71感染的预防及治疗提供了新的途径。本文对EV71病毒学特点及抗EV71药物的筛选、疫苗开发、RNA干扰等进行了综述, 以期为相关研究提供参考。

Abstract:

Hand, foot, and mouth disease (HFMD) outbreaks have been reported in many areas, especially in Aria. Enterovirus 71 (EV71) is the major causative pathogen of HFMD in children and infants, its infection usually accompanied with severe neurological complication which causes high mortality. In recent years, the molecular biology study of EV71 and the progress of antiviral therapies development provide us new strategies for the treatment and prevention of EV71 infection. This paper reviewed the latest achievements in virology and antiviral agents of EV71, including drugs, vaccine, and RNA interference etc, which may be expected to serve as references for related research.