白念珠菌铁稳态调控网络研究进展

Research advances of iron homeostasis regulatory networks in Candida albicans

摘要:

铁是绝大多数生物生长和代谢过程中必需的营养元素。尽管自然界中铁元素含量非常丰富, 但是其生物可利用性却很低。作为一种人体常见的条件致病真菌, 白念珠菌在漫长的进化过程中形成了复杂的铁稳态调控网络, 能够应答环境中铁浓度的变化, 增强菌株对环境的适应力。结合课题组研究工作, 简要综述近几年关于铁代谢表达调控途径的研究进展, 主要关注白念珠菌在环境铁匮乏条件下铁获得和调控策略, 揭示白念珠菌体内铁离子摄取、转运、储存和利用机制。

Abstract:

Iron is an essential element that is required for the growth and normal metabolism in most organisms. However, despite its much abundance in the Earth’s crust, the bioavailable form of iron is very poor. To obtain iron in the environment, Candida albicans, as a common opportunistic human fugal pathogen, has evolved the iron regulatory networks to respond to the fluctuations in iron availability, which is associated with the adaptation to the hostile environment. As well as our study, this paper reviews the research advances of iron regulatory networks in recent years, focusing on the iron acquisition and regulatory strategies exhibited by C. albicans when it responds to iron deprivation. This review also provides an insight into the mechanisms that how cells sense, transport, store and utilize iron.