枯草杆菌耐药转运蛋白Bmr及其基因bmr的表达调控研究进展

Advances in multidrug resistance transporter Bmr of Bacillus subtilis and transcriptional regulation mechanism of its gene bmr

摘要:

枯草杆菌多重耐药转运蛋白Bmr是其主要的耐药外排蛋白之一, 由位于基因组DNA的bmr基因编码, 介导对多种抗生素、杀菌剂等药物的耐药性。bmr基因的表达受到BmrR及MtaN的转录调控, 二者均属于MerR家族调节子。关于近年对多重耐药转运蛋白Bmr和调节蛋白BmrR、MtaN的结构、生理功能及作用机制等研究情况进行综述。

Abstract:

Multidrug transporter Bmr is one of the main drug resistance efflux proteins in Bacillus subtilis. It’s encoded by bmr gene which is located in the genome, and it mediates the resistance to a wide range of drugs such as antibiotics and antimicrobials, etc. The expression of bmr gene is regulated by BmrR and MtaN, both of which are transcriptional regulator from the MerR family. This paper reviewed the study of structure, physiological function and the action mechanism of Bmr and the regulatory protein BmrR and MtaN in recent years.