细菌应激反应中(p)ppGpp代谢的调控

Modulation of (p)ppGpp metabolism during bacterial stringent response

摘要:

(p)ppGpp是介导细菌细胞对环境胁迫产生应激反应的重要胞内信号, 通过控制一系列重要的细胞活动使细菌得以生存。通过对蓝细菌中(p)ppGpp代谢的研究，对(p)ppGpp作用机制、控制(p)ppGpp代谢的酶系统、环境胁迫信号传递、细胞中(p)ppGpp水平的调控及其多样性进行了总结。

关键词:环境胁迫, 应激反应, (p)ppGpp, 代谢调控

Abstract:

(p)ppGpp is a well known intracellular signal that mediates bacterial stringent response to environment stresses through the change of its concentration level thus controls many important cellular processes for bacterial survival. In this review, we outline the mechanism of (p)ppGpp action, the enzyme system involved in (p)ppGpp metabolism, and summarize the signal transmission, the regulation and the diversity of (p)ppGpp metabolism. Moreover, we give a brief introduction on our achieved results recently about (p)ppGpp metabolism in cyanobacteria, and predict that a (p)ppGpp new metabolic mechanism different from those known exists in cyanobacteria.

Key words:Environment stress, Stringent response, (p)ppGpp metabolism, Modulation