过氧化物酶体与病原真菌的致病性

Peroxisome and pathogenicity of pathogenic fungi

摘要:

过氧化物酶体(Peroxisome)是一类单层膜的细胞器, 普遍存在于各种真核细胞中。过氧化物酶体是丰富的酶库, 含有至少50种酶类, 参与生物体的多种生理代谢过程, 如乙醛酸循环、脂肪酸的β-氧化及活性氧的调节等。近年来, 日益增多的研究表明过氧化物酶体和病原真菌的乙醛酸循环及脂肪酸的β-氧化功能的发挥密切相关, 并影响病原真菌的致病性。总结过氧化物酶体中酶的种类和功能, 评述过氧化物酶体与乙醛酸循环、脂肪酸β-氧化和病原真菌致病性的关系。

Abstract:

Peroxisome, an organelle with a single membrane, lies in various eukaryotic cells. Peroxisome contains more than 50 enzymes, involved in multiple physiological metabolic processes in organisms, such as the glyoxylate cycle, β-oxidation of fatty acid and regulation of active oxygen. Recently, increasing studies showed peroxisome influence on the glyoxylate cycle, β-oxidation of fatty acid, and pathogenicities of pathogenic fungi. In this review, types and functions of enzymes in peroxisome, metabolic processes related to peroxisome and relationship between peroxisome and pathogenicities of pathogenic fungi were summaried.