γ-聚谷氨酸的微生物合成、相关基因及应用展望

Biosynthesis of poly (γ-glutamic acid), its related genes and application prospects

摘要:

γ-聚谷氨酸是一种具有极强水溶性、生物相容性、可完全降解性的环境友好型新材料。介绍了γ-聚谷氨酸的基本性质、微生物合成及其影响因素, 综述其合成相关基因、合成酶复合体的研究进展及在水凝胶和药物载体方面的应用前景。

Abstract:

Poly (γ-glutamic acid) is a promising environmental friendly material with outstanding water solubility, biocompatibility and degradability. This review introduces the basal properties of γ-PGA, microbial production of γ-PGA, and the key factors affecting the yield of γ-PGA. Furthermore, the γ-PGA biosynthesis genes, γ-PGA synthetase complex, as well as the application prospects of γ-PGA in hydrogel and drug delivery, are also discussed.