三种药用植物内生菌的分离及其抗肿瘤活性菌株的筛选

Isolation and Screening for Endophyte with Antitumor Activities from Three Medicinal Plants

摘要:

对204株分离自长春花、海南粗榧和见血封喉的内生菌进行了抗肿瘤活性筛选。结果显示, 有19株内生菌的发酵液至少对一种指示瘤株具有细胞毒活性, 其中4株菌的发酵液对S180的抑制率较强, 均在70%以上。研究表明菌株PA09006和PA09009发酵液中的抗肿瘤活性物质, 具有一定的酸碱耐受性, 并且对温度和紫外线具有一定的稳定性。

Abstract:

Two hundred and four endophytes isolated from Catharanthus roseus, Cephalotaxus hainanensis and Antiaris toxicaria were screened for antitumor activities. The results showed that broth of 19 strains presented cytotoxic activities to at least one of the tested tumor cells, four of them exhibited strong antitumor activity against S180, were above 70%. Studies have shown that broth in the antitumor active substances of strains PA09006 and PA09009, confer a certain to pH value and ultraviolet.