PLGA纳米/微球作为核酸载体的研究进展

Research Progress on PLGA Nanoparticles/Microspheres as DNA Carriers

摘要:

生物可降解材料[poly(lactide-co-glycolide acid), PLGA]颗粒在持续释放和定位递送各种药剂包括核酸有很大的研究和应用价值。本文综述了PLGA作为核酸载体的制备及其用于基因载体和疫苗佐剂的研究。

Abstract:

Biodegradable PLGA [poly(lactide-co-glycolide acid)] have shown significant potential for sustained and targeted delivery of several pharmaceutical agents, including DNA. We reviewed the formulating approaches of PLGA nanoparticles/microspheres as DNA carriers and utilization for gene therapy and vaccine adjuvant.