1. State Key Laboratory of Bioreactor Engineering, Newworld Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, China; 2. Key Laboratory of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Chine 在期刊界中查找 在百度中查找 在本站中查找
State Key Laboratory of Bioreactor Engineering, Newworld Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, China 在期刊界中查找 在百度中查找 在本站中查找
State Key Laboratory of Bioreactor Engineering, Newworld Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, China 在期刊界中查找 在百度中查找 在本站中查找
State Key Laboratory of Bioreactor Engineering, Newworld Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, China 在期刊界中查找 在百度中查找 在本站中查找
1. State Key Laboratory of Bioreactor Engineering, Newworld Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, China; 2. Key Laboratory of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Chine 在期刊界中查找 在百度中查找 在本站中查找
Laboratory of Microbial Metabolism and School of Life Science & Biotechnology, Shanghai Jiao Tong University, Shanghai 200030, China 在期刊界中查找 在百度中查找 在本站中查找
Based on founding the methods for isolation and purification of the novel decarboxylated FR-008/Candicidin derivative CS103, we obtained enough samples for testing from the culture mycelia of the mutant of Streptomyces FR-008. Through comparing the cell toxicities on Human Embryonic Kidney Cells 293, haemolytic activities on human erythrocytes and antifungal activities on C. albicans, we found that the toxicity of decarboxylated FR-008/Candicidin derivative CS103 had been lower than FR-008/Candicidin and Amphoteicin B, while it still had high antifungal activity on C. albicans.
