口蹄疫新型疫苗研究进展

Recent Advances of New-type Foot-and-mouth Disease Vaccines

摘要:

口蹄疫(FMD)是一种严重威胁畜牧业发展的重要传染病, 目前世界上许多国家和地区都有该病的流行与发生。其控制措施主要是疫苗免疫, 虽然传统疫苗在该病的防控中起了重要的作用, 但也存在着诸多的缺点。因此研制新型的FMD疫苗是今后的发展方向。本文结合实验室在FMD新型疫苗研究方面所开展的探索性研究工作, 综述了国内外在FMD基因工程弱毒苗或灭活苗、蛋白质和合成肽疫苗、空衣壳疫苗、细胞因子增强型疫苗等研究领域所取得的进展。

Abstract:

Foot-and-mouth disease is a devastating disease of livestock that has had a significant impact on world economies and prevailed in many countries and areas throughout the world. Although the traditional inactivated vaccine is effective, there are a number of concerns with its use. So many researchers have attempted to develop new vaccines that may provide additional tools to help control FMD in future. In this paper, based on the research work in our lab, we reviewed the international research progress on the new-type vaccines of FMD including genetically engineered live-attenuated or inactivated vaccines, protein and synthetic peptide vaccines, empty capsid vaccines, and cytokine-enhanced vaccines.