谷胱甘肽与铜绿假单胞菌致病性的关系

The Relationship Between Glutathione and the Pathogenicity of Pseudomonas aeruginosa

摘要:

铜绿假单胞菌由于对抗生素的固有耐药和多重抗药性, 已成为医院内感染的重要病原菌之一。谷胱甘肽是细胞内最重要的抗氧化剂, 保护细胞免受氧化压力的损害。但是在铜绿假单胞菌感染的组织中, 由于绿脓菌素等致病因子的存在, 可以导致谷胱甘肽的水平降低。同时, 谷胱甘肽又可以增强绿脓菌素的致病性。本文就谷胱甘肽与铜绿假单胞菌关系的最新研究进展并结合作者的工作, 对上述问题进行了综述和探讨。

Abstract:

Pseudomonas aeruginosa is one of the most common causes of nosocomial infection due to its intrinsic resistance to antibiotics. In the host, glutathione (GSH), one of the most important intracellular antioxidants, provides protection against high levels of oxidative stress. A decrease in GSH levels in tissues infected with P. aeruginosa has been observed while interactions between pyocyanin and GSH maybe partially attribute to P. aeruginosa infection. In this review, the relationship between GSH and the pathogenicity of P. aeruginosa has been discussed based on the author’s own research results and the latest literature.