新型微生物脂肪酶资源开发

Development of Novel Microbial Lipase Resources

摘要:

微生物脂肪酶是一类重要的工业生物催化剂, 广泛应用于工农业生产的诸多领域。筛选、挖掘和开发出具有新型催化活性或高稳定性的微生物脂肪酶一直是脂肪酶研究的重点。本文从极端微生物、宏基因组技术、基因组数据库挖掘、定向进化技术、固定化技术和化学修饰技术等方面介绍了当前新型脂肪酶开发的途径和方法。

Abstract:

Microbial lipase, one of important industrial biocatalysts, has been used widely in many industrial and agricultural fields. It is always the research focus to screen, mine and develop the microbial lipases with novel catalytic activity and high stability. This paper introduces briefly the pathways and methods to mine novel microbial lipase resources from six aspects, including extremophile, metagenome, genome database, protein engineering, immobilization, chemical modification, etc.