费氏链霉菌HTP6分批发酵动力学

Kinetics of Streptomyces fradiae HTP6 in the Batch Fermentation Process

摘要:

对费氏链霉菌HTP6产新霉素的分批发酵动力学进行了研究, 并建立了动力学模型。对数生长期最大比生长速率μm为0.0866 h-1, 产物合成期最大合成速率qp为1.1867×10-4 g/(mL×h)。对实验数据与模型模拟值进行拟合检验, 表现出很好的适用性, 实验平均相对偏差小于5%。表明该动力学模型对费氏链霉菌产新霉素的发酵生产具有实际意义。

关键词:费氏链霉菌, 新霉素, 发酵, 动力学模型

Abstract:

The kinetics of neomycin productions by batch fermentation with Streptomyces fradiae HTP6 were studied. The mathematical kinetic models describing the course of Streptomyces fradiae HTP6 fermentation were established. The maximal specific growth rate μm was 0.0866 h-1 in exponential phase. The maximal specific production rate qp could reach 1.1867×10-4 g/(mL·h) in antibiotic production phase. The calculated results of models were compared satisfactorily with experimental data, the average relative deviation was no more than 5%. This kinetic model had practically guiding producing neomycin in fermentation of Streptomyces fradiae.

Key words:Streptomyces fradiae, Neomycin, Fermentation, Kinetics model