细菌生物膜与耐药性相关性研究进展

Progress on the Relevance of Bacteria Biofilm to Antibiotic Resistance

摘要:

细菌生物膜是一种包裹于细胞外多聚物基质中不可逆的黏附于非生物或生物表面的微生物细胞菌落。生物膜状态下的细菌相对其浮游状态具有显著增强的耐药性, 对人及动物细菌性感染具有重要研究价值。然而尽管动物细菌耐药性被广泛报道, 却很少涉及细菌生物膜与其之间的相关性, 本文综述了细菌生物膜的耐药机制并探讨了细菌生物膜与动物源性细菌耐药性的关系, 可作为研究细菌耐药性及控制动物产品安全的参考。

Abstract:

Bacterial biofilm is a biopolymer matrix-enclosed bacterial population adherent to each other and surfaces or interfaces. The organisms within biofilms are notorious for their resistance towards antibiotics compared to their free-living planktonic counterparts. Consequently, biofilms are of significant importance to both clinical and veterinary science. However, although antibiotic resistance of bacteria are widely reported in animals, their association with biofilms is rarely discussed. The aim of this review is to look at the mechanism of antibiotic resistance of bacterial biofilms and discuss the relevance between antibiotic resistance of animal bacteria and biofilms, besides this article can be seen as a reference in studying antibiotic resistance in bacteria and guaranteeing the safety of animal products.