沙门氏菌抗生素抗性机理研究进展

Progress on Studies of Mechanism of Antibiotic Resistance of Salmonella

摘要:

沙门氏菌的多重耐药性问题已经成为世界范围内的公共卫生和经济问题。目前沙门氏菌抗生素抗性机理的研究主要集中以下方面：(1)基因突变与抗生素抗性; (2)外排泵与抗生素抗性; (3)耐药基因编码的钝化酶和灭活酶引起的抗生素抗性; (4)可移动的细菌遗传耐药基因元件及其转移与抗生素抗性。本文基于以上几个方面综述了与沙门氏菌抗生素抗性机理研究相关的研究动态和研究进展。

Abstract:

Multidrug-resistant Salmonella has become a public health and economic problem worldwide. Antibiotic resistance in bacteria can be caused by gene mutation, overexpression of efflux pumps, and mobile genetic elements such as plasmids and integrons that carry genes encoding enzyme(s) that inactivates or modifies antibiotics. This review focuses on research progress related to elucidating mechanism of antibiotic resistance in Salmonella.