葡萄球菌生物膜形成机制与ica之间的关系

The Relationship Between Staphylococcal Biofilm Formation Mechanism and ica locus

摘要:

ica位点编码的胞外多糖(PIA/PNAG)对理解葡萄球菌生物膜相关感染病理学方面具有重要的意义。关于ica位点与PIA/PNAG之间如何调节的研究还不全面, 另外一种独立于ica的生物膜形成机制存在于表皮葡萄球菌和金黄色葡萄球菌中; 细胞表面相关蛋白也能调节生物膜的形成, 这些发现为探究它们在生物膜形成机制的潜在作用提供了重要基础。

Abstract:

The role of the ica locus-encoded polysaccharide intercellular adhesin (PIA/PNAG) has contributed a lot to the pathogenesis of device-related infections of staphylococcal biofilm. Understanding of how the ica locus and PIA/PNAG biosynthesis are regulated is not enough. Another biofilm formation mechanism of ica-independent in both Staphylococcus aureus and Staphylococcus epidermidis exists. The cell surface associated proteins are capable of mediating biofilm formation. Future research about their potential role in biofilm development will be very important.