宿主-病毒在miRNA水平上的相互作用

Host-virus Interaction at the miRNA Level

摘要:

微RNA(microRNA, miRNA)是近来发现的重要基因调节子, 在许多生物学过程包括抗病毒防御中发挥着重要作用。越来越多的证据表明一些病毒或者编码它们自己的miRNAs或者颠覆细胞miRNAs。由此, 宿主和病毒编码miRNAs及其靶标形成了宿主和病毒间新一调节层面的相互作用。深入理解宿主-病毒间miRNAs介导的相互作用, 不仅有利于阐明病毒致病的分子基础, 而且有利于制定更好的治疗策略。

关键词:宿主, 病毒, 相互作用, miRNA

Abstract:

MicroRNAs (miRNAs) are recently discovered major regulators of gene expression, which play a pivotal role in a wide spectrum of biological processes including antiviral defence. There is growing evidence that some viruses either encode their own viral miRNAs or subvert cellular miRNAs. The host- and virus-encoded miRNAs and their targets together thus form a novel regulatory layer of interactions between the host and the virus. A better understanding of host-virus interaction mediated by miRNAs would not only enable us to unravel the molecular basis of viral pathogenesis, but also enable us to develop better therapeutic strategies.

Key words:Host, Virus, Interaction, miRNA