胺基裂解酶及其在医药中间体生产中的应用

Amine-lyases and Their Applications in Preparation of Pharmaceutical Intermediates

摘要:

C-N裂解酶(E.C.4.3)是能催化释放氨、脒和胺基等并形成双键或环的一类酶。胺基裂解酶(E.C.4.3.3)就是其中能够催化释放胺基的一类酶, 该类酶在医药中间体生产中起关键酶的作用。本文概述了4种胺基裂解酶的来源, 酶学特性以及它们在医药中间体生产中的应用。

Abstract:

Carbon-nitrogen lyases (E.C.4.3) are a group of enzymes that release ammonia, amidine or amino group etc,?and also show ability to form double bond or ring structure. Specifically, enzymes forming amino group are called amine-lyases (E.C.4.3.3), which are critical in the industrial production of many medicine intermediates. In this review is a summary of four major amine-lyases in terms of their source, enzymatic characteristics and their applications in preparation of pharmaceutical intermediates.