硫酸乙酰肝素与口蹄疫病毒感染

Heparan Sulfate and Foot-and-mouth Disease Virus Infection

摘要:

受体是病毒宿主嗜性和致病机制的主要决定因素。硫酸乙酰肝素(HS)是一种多聚阴离子碳水化合物, 广泛存在于真核细胞的细胞膜和细胞基质。HS是许多病毒在细胞膜上的特异受体或辅助受体。目前发现口蹄疫病毒可利用HS和整联蛋白(αvβ3、αvβ6、αvβ1、αvβ8)作为病毒受体。口蹄疫病毒可能在不同的感染阶段利用不同类型的受体与宿主细胞相互作用。研究病毒受体的结构和功能对理解病毒与宿主细胞的关系具有重要意义。本文主要论述了HS的生物学特性及其与口蹄疫病毒感染的关系。

Abstract:

Receptors are primary determinant of viral tropism and disease pathogenesis. Heparan sulfates (HS) are ubiquitous, polyanionic carbohydrate chains linked to core proteins in cell membranes and extracellular matrices of all eukaryotes. HS have also been demonstrated to function as receptors or co-receptors for a number of different viruses. To date, HS and four RGD-dependent integrins, αvβ3, αvβ6, αvβ1, and αvβ8 have been reported to serve as receptors for Foot-and-mouth disease virus (FMDV). Different receptors may be used to interact with host cells during FMDV infection. Studies on the structure and function of receptors are very important for understanding the interaction between host cells and FMDV. Here, We mainly reviews the progress on the biological characteristics of HS and its roles in FMDV infection.