Abstract:In the context of the deep integration between emerging engineering education and industry-education collaboration, graduate course instruction urgently requires a departure from the conventional model of knowledge transmission. Instead, it must focus on cultivating higher-order competencies, particularly those centered on innovation capability and practical literacy. As a cutting-edge core course in life sciences, Epigenetics presents challenges due to its abstract content and rapid evolution, while conventional teaching methods often suffer from a disconnect between theoretical knowledge and industrial practice, which complicates instructional implementation. This study, grounded in constructivist learning theory and the “learning by doing” paradigm, utilizes authentic industrial scenarios and project resources from the Science and Technology Backyard (an industry-education collaboration platform that combines talent cultivation, technological innovation, and social services, here, teachers and students engage at production frontlines to achieve seamless alignment between research and industrial needs), a “scenario-module” dual-teaching mode is constructed and implemented through the following pathways. Scenario-driven learning focuses on real-world industry issues within the Technology Extension Hub embedding course contents into specific production contexts to transform abstract theories into tangible practical scenarios. Modular restructuring organizes the course into three core modules: fundamental epigenetic theories, industrial application technologies, and frontier research topics, each deeply integrated with industry settings such as the Technology Extension Hub, thereby forming a closed-loop chain of theory-technology-application. Through the integration of project-based learning (PBL) with a dual-mentor model (comprising coordinated guidance from both academic and industry mentors) restructures the pedagogical process to enable students to engage in systematic, rigorous, and contextually grounded training centered on authentic industrial challenges. Reform practices have demonstrated that this model effectively addresses the disconnection between theory and practice commonly found in conventional teaching methods. It significantly enhances students’ overall capabilities in deep knowledge comprehension, scientific research and innovative thinking, technical solution design, and interdisciplinary problem-solving within industrial contexts. This model offers both practical pathways and theoretical support for graduate education reform in cutting-edge interdisciplinary fields such as life sciences, agriculture, and microbial technology.