Abstract:Universities, as the cradle for cultivating students’ innovation capability, regard nurturing high-quality talents with professional knowledge, critical thinking, and innovation capability as the fundamental purpose and mission of higher education. For a long time, the higher education in China has lacked the concept of individualized and innovative education, and a comprehensive system for cultivating college students’ innovative thinking and practical skills remains to be established. Following the concept of outcome-based education (OBE), this study takes students as the center to train their innovation capability by virtue of the undergraduate microbiological research interest group and stimulate their innovative thinking by a series of activities. According to the philosophy of combination of teaching and research and the application needs, we guide group students to participate in scientific research and production practice. By participating in the “Challenge Cup”, “Internet+”, national life science competition and other projects, students enhance their research innovation capability and practical skills. Our team combines the training process with the feedback mechanism to perfect the training and evaluation system of students’ innovation capability, providing the train of thought and method for the fostering the innovation capability of science talents in normal universities and ordinary universities.