Abstract:With the deepening reform of higher education, general education plays an increasingly important role in enhancing students’ comprehensive competencies. Wuhan University offers a general education course titled “The World of Microorganisms” for undergraduate students not majoring in life sciences. Guided by the principle of using national undertakings to hone young people’s capabilities, teaching reforms oriented toward serving national strategies are carried out for this course. We reconstruct the chapter organization and case system around microbial resource development, biosafety prevention and control, and eco-environmental protection. Building on the integrated practical chain of national needs-research platforms-practical teaching, the course is designed to encompass the learning activities such as mushroom cultivation, environmental microbial detection, and visits to China Center for Type Culture Collection. Additionally, AI intelligent platform is introduced to support co-construction of mind maps, word cloud-based visualization of class discussions, and real-time Q&A feedback, supplemented by a multi-dimensional evaluation mechanism covering the entire process. Following these reforms, students demonstrated significant improvements in class participation, scientific spirit, and recognition of social responsibility. This study summarizes the instructional design and implementation pathway for general education courses oriented toward national strategy, providing replicable paradigms and experience for the reform of general education courses in natural sciences.