基于文献计量学的蛹虫草研究热点可视化分析

Visual analysis of research hotspots on Cordyceps militaris based on Bibliometrics

摘要:

【背景】蛹虫草(Cordyceps militaris)作为虫草科虫草属的模式种一直受到全球研究人员的关注。【目的】多维度探讨蛹虫草研究的当前状况与未来趋势。【方法】基于Web of Science核心合集数据库对2005−2024年间有关蛹虫草的SCI核心集论文进行了全面的数据搜集、整理、分析和可视化处理。【结果】过去20年里，蛹虫草研究已从单一的培养特性拓展至跨学科领域，尤其是其活性成分和药理学效应已成为学术界关注的焦点。文献计量分析结果显示，2005−2009年间，主要研究方向为蛹虫草的人工培养。2010−2014年间，研究主题扩展至子实体相关的药理学，研究地位显著提升。2015年后，研究主题进一步多元化，涵盖了优化、表达、氧化应激、真菌、抗氧化剂、化学成分、Nf-κB、细胞周期停滞等领域，显示了从培养技术向深入的生物学和医学机制研究的转变。【结论】蛹虫草的研究经历了从传统培养研究向多学科交叉的深刻变革，未来研究将更加侧重于活性成分的功能机制、生物活性物质的药理作用及潜在的医学应用，为蛹虫草的深入研究和开发利用提供科学依据。

Abstract:

[Background] Cordyceps militaris, as the model species of the genus Cordyceps in the family Cordycipitaceae, has been receiving global attention from researchers. [Objective] This study employs Bibliometric methods to comprehensively examine the current state and future trends of C. militaris research from multiple dimensions. [Methods] we comprehensively retrieved, organized, analyzed, and visualized the papers related to Cordyceps militaris from Web of Science core collection that were published from 2005 to 2024. [Results] In the past two decades, the research on C. militaris expanded beyond cultivation characteristics to interdisciplinary fields, with a particular focus on its active components and pharmacological effects. The artificial cultivation of C. militaris was the main research direction from 2005 to 2009. From 2010 to 2014, the research topics encompassed the pharmacology of the fruiting bodies. After 2015, research topics became diversified, covering optimization, expression, oxidative stress, fungi, antioxidant, chemical-composition, Nf-κB and cell cycle arrest. This shift indicated a transition from cultivation techniques to the in-depth research on biological and medical mechanisms. [Conclusion] The research on C. militaris evolved from conventional cultivation to multidisciplinary fields. The future research is expected to focus mainly on the functional mechanisms, pharmacological effects, and potential medical applications of bioactive substances, providing a scientific basis for the in-depth study and development of C. militaris.