丁酸梭菌及其代谢物丁酸对炎症性肠病影响的研究进展

Research advances in the effects of Clostridium butyricum and its metabolite butyrate on inflammatory bowel disease

摘要:

炎症性肠病(inflammatory bowel diseases, IBD)发病机制复杂，缠绵难愈且易癌变，现有药物疗效未达预期且不良反应较多，亟须寻找新的治疗药物。而丁酸梭菌(Clostridium butyricum)及其代谢产物丁酸是近年来发现对肠黏膜屏障具有保护作用的一类益生菌及代谢物，但其具体作用机制有待归纳和总结。本文系统总结了C. butyricum和丁酸通过影响肠道屏障功能在IBD发病机制中作用的研究进展，以及其在炎症性肠病治疗中的潜在临床价值，以期为IBD发病机制的探究、治疗方式的创新提供新视角和思路。

关键词:丁酸梭菌;丁酸;炎症性肠病;肠道屏障

Abstract:

Inflammatory bowel disease (IBD) is a complex and chronic inflammatory disease that is challenging to be cured and prone to carcinogenesis. Existing medications for IBD have limited efficacy and often come with adverse effects, which necessitates the development of new therapies. Clostridium butyricum and its metabolite, butyrate, have recently been identified as a probiotic and a metabolite, respectively, that offer protective benefits to the intestinal mucosal barrier. However, the specific mechanisms underlying their actions remain to be elucidated. Therefore, this article comprehensively reviews the research progress in the roles of C. butyricum and butyrate in the pathogenesis of IBD via influencing the intestinal barrier function, as well as their potential clinical values in the treatment of IBD. The findings will give novel insights into the research on the pathogenesis and innovation of the therapies of IBD.

Key words:Clostridium butyricum;butyrate;inflammatory bowel disease;intestinal barrier