布鲁氏菌感染与宿主细胞程序性死亡博弈

“Battle” between Brucella infection and programmed cell death of the host cell

摘要:

布鲁氏菌病(简称布病)是由布鲁氏菌(Brucella)感染引起的一种重要人兽共患细菌病，目前呈全球流行态势。布病对人兽健康造成严重威胁，并给局部地区带来巨大的社会经济负担。布鲁氏菌侵入宿主体内并建立长期甚至终身感染，离不开其精巧的免疫逃逸机制和复杂的胞内复制机制。调控宿主细胞死亡，如细胞凋亡、焦亡和自噬等，是布鲁氏菌免疫逃逸机制的重要环节。因此，深入研究布鲁氏菌调控宿主细胞程序性死亡的方式及其作用，能够为深入解析布鲁氏菌致病机制、挖掘药物靶标提供有益的参考价值。基于此，本文总结了近些年关于布鲁氏菌感染与宿主细胞多种程序性死亡之间的精密调控及其之间的“对弈”进展。

关键词:布鲁氏菌;免疫逃避;程序性细胞死亡;凋亡;焦亡;自噬

Abstract:

Brucellosis caused by Brucella infection is a major bacterial zoonosis, presenting a global prevalence situation. Brucellosis poses severe threats to the health of human and livestock, imposing substantial socio-economic burdens in certain regions. The invasion and establishment of chronic or even lifelong infection by Brucella in the hosts largely reply on its sophisticated immune evasion strategies and complex intracellular replication mechanisms. The manipulation of programmed cell death, such as apoptosis, pyroptosis, and autophagy, is a key strategy for the immune evasion of Brucella. Therefore, in-depth research on the ways Brucella regulates programmed cell death in host cells and their significance can provide valuable references for understanding the infection mechanism of Brucella and identifying potential drug targets. This paper summarizes the recent progress in the precise regulatory mechanisms and the “battle” between Brucella infection and various forms of programmed cell death in hosts.

Key words:Brucella;immune evasion;programmed cell death;apoptosis;pyroptosis;autophagy