产甘油假丝酵母及其研究进展

Research progress inCandida glycerinogenes

摘要:

产甘油假丝酵母(Candida glycerinogenes)是一株具有50多年研究史的自主知识产权菌株，本课题组利用该菌建立了全球最高产量的甘油好氧发酵工业化技术。随着近年来对该菌研究的不断深入，发现其具有很强的抗逆性和高效的糖代谢能力，是非常有潜力的合成生物学工业底盘细胞。本文通过对C.glycerinogenes的发现过程、特点、国内外发酵甘油技术工业化，以及其在分子操作系统、信号应答和代谢工程等方面的研究进展进行论述和回顾，并对未来的发展方向进行展望，为建立起自主产权和创新的合成生物学体系提供借鉴和参考。

Abstract:

Candida glycerinogenesis a strain with independent intellectual property right and more than 50 years of research history. Our research group has established the aerobic fermentation technology with this strain for glycerol production and achieved the world’s highest yield. As the research on this yeast is deepening in recent years, researchers have discovered that C.glycerinogenes has strong resistance and high efficiency of sugar metabolism, demonstrating the potential of serving as an industrial chassis cell for synthetic biology. This paper reviews the discovery process and characteristics of C.glycerinogenes, the industrialization of fermentation technology for glycerol production, and the research progress in the molecular operating system, signaling responses, and metabolic engineering of this yeast, and makes an outlook on the future direction of development, aiming to provide reference for establishing an innovative synthetic biology system with independent property right.