微生物来源的尿酸氧化酶的研究进展及应用前景

Research Progress on the Microbial Urate Oxidase

摘要:

尿酸氧化酶是一种重要的医药用酶，它催化嘌呤代谢途径中的尿酸氧化生成尿囊素和过氧化氢，因而被广泛用于治疗痛风，检测血液尿酸浓度，预防和治疗由于肿瘤化学治疗引起的高尿酸血症。综述了尿酸氧化酶的来源、酶学性质、基因克隆与表达及其用途，并对其在应用中存在的问题和前景作了展望。

Abstract:

Urate oxidase belonging to the purine degradation pathway, catalyzes the oxidation of uric acid to allantoin. It′s useful for enzymatic determination of urate in clinical analysis. It can also be used as protein drug for treatment of gout, hyperuricemia and tumor lysis syndrome (TLS). The source, enzyme property, genetic engineering and application of uricase were reviewed in this paper.