可培养海洋放线菌生物多样性的研究进展

Progress in the Bio-diversity Studies of Culturable Marine Actinobacteria

摘要:

海洋放线菌是新药开发和天然活性产物的重要来源，海洋放线菌的生物多样性是代谢产物功能多样性的基础，因此研究可培养放线菌的生物多样性具有重要的意义。综述了近年来可培养的海洋放线菌生物多样性的研究进展，尤其是海绵共附生放线菌、深海放线菌和海洋固有放线菌的研究进展，对可培养的海洋放线菌的分离培养方法,包括样品处理、培养基的选择等进行了重点介绍，并对未培养海洋放线菌的分离培养进行了探讨，强调了建立区域性海洋放线菌菌种及基因资源库的重要性。

Abstract:

Marine actinobacteria are novel sources for drug discovery and active natural products. Since the functional diversity of active metabolites from marine actinobacteria originates from the Bio-diversity of this important group of gram-positive bacteria, studies on the diversity of culturable marine actinobacteria are of great importance. In this review, the progress in the diversity studies of marine actinobacteria, especially the research in the marine sponge-associated actinomycetes, deep sea actinomycetes and the indigenous marine actinomycetes was reported. Meahwhile, the isolation techniques including the pre-treatment of samples and the selection of media were highlighted. The cultivation of as yet unculturable marine actinobacteria was discussed, and the importance of establishing regional centers for marine actinobacteria strain and gene resources was emphasized.