Abstract:The process and mechanism of chitin degradation in Vibrios were introduced in this paper by reviewing of recent progress in chitin catalytic cascade research. There exist three steps in chitin degradation, hydrolysis of chitin, transportation of chitin oligosaccharides and N-acetylglucosamine, and further degradation of chitobiose and N-acetylglucosamine-6-phosphate. Most of the reactions in chitin degradation are regulated by two-component signal transduction system.