Toll样受体在烟曲霉侵染宿主细胞过程中作用的研究进展

Advance in Study on the Role of Toll-like Receptors During the Invasion of Aspergillus fumigatus into Host Cell

摘要:

烟曲霉侵染宿主细胞时伴有明显的细胞肌动蛋白骨架重排，而重要模式识别受体PRRs（pattern recognition receptors）之一，Toll样受体（Toll-like receptors, TLR）参与调节病原细菌诱导的宿主细胞肌动蛋白骨架重排，其中TLR2和TLR4两亚型可以识别烟曲霉的病原相关分子模式PAMP（pathogen-assosiated molecular patterns），并诱发炎症因子表达等一系列效应信号，在宿主细胞抗烟曲霉天然免疫中发挥重要作用，但在烟曲霉内化侵入过程中TLR能否特异性介导细胞肌动蛋白骨架重排尚不清楚。因此，研究揭示TLR激活在烟曲霉侵入宿主细胞的调控作用，对寻找可能的抗真菌药物作用靶点具有重要意义。

Abstract:

During invasion of Aspergillus fumigatus into host cells，there is an obvious cellular actin cytoskeleton rearrangement. Toll-like receptors (TLRs)，one of the most important PRRs （pattern recognizing receptors）, can tigger the intracellular signaling transduction to induce the innate immunity, meanwhile be involved in regulating bacteria-associated cellular actin cytoskeleton rearrangement. The PAMPs(pathogen-assosiated molecular patterns) of Aspergillus fumigatus can be recognized by TLR2 and TLR4, nevertheless, the role of TLRs in the regulation of cellular actin cytoskeleton rearrangement during invasion remains unclear. Further studies on the internalization of Aspergillus fumigatus through TLRs will contribute significantly to our understanding of regulation on invasion of Aspergillus fumigatus, eventually provide some ways to cure the fungal infection.