Puff-balls is a very distinctive macro-fungi in biodiversity.It is used to be a styptic,repellent and alexipharmic in China.This paper simply summarizes the puffball′s taxonomy in the fungi and its distribution in the world; and emphasizes on its composition,food uses,medical uses,herbalism studies and progress of researches on clinical applications.And it points out the patent prospect and current problems of the puff-balls.