多聚酮的微生物合成及其多样性研究进展

Advances on Polyketide Biosynthesise by Microorganism and the Diversity of Polyketide Synthases

摘要:

多聚酮多是由微生物产生的一大类天然产物,在结构和功能上具有多样性。很多聚酮具有抗细菌、抗真菌、抗寄生虫、抗肿瘤等生物活性,有很大的临床应用价值。随着研究的不断深入,一方面更多的天然产物聚酮被发现。另一方面对它们合成相关酶的作用机制研究也更加深入。主要对多聚酮的合成机制以及多聚酮合成类型的多样性展开论述。

Abstract:

Polyketides are very large group of natural products with functional and structural diversity.Most of them are produced by microor- ganism and have medicinal activities,including antibiotic,anticancer,antifungal and antiparasitic properties.The researchs in this area have progressed greatly.More and more polyketides are discovered,on the other hand the mechanisms of biosynthesis of those various polyketides are researched more deeply and clearly.The article reviewed the progress of the research in the diversity of polyketide synthases and the mechanisms of polyketide biosynthesise.