Abstract:Zoonoses pose a serious threat to human health and affect animal husbandry and public health security. Vaccination is an important means of preventing the spread of these diseases. As a novel type of candidate vaccines, bacterial ghost-based vaccines demonstrate broad application prospects because they can induce strong humoral, cellular, and mucosal immune responses. Moreover, they are praised for the simple fermentation production and purification processes and high safety. This paper briefs the preparation technology and immune response-triggering mechanism of bacterial ghosts and reviews the research progress of bacterial ghosts in brucellosis, a major bacterial zoonosis in animals, aiming to provide valuable reference for the development of novel vaccines.
