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微生物学通报

地衣放线菌活性次级代谢产物研究进展
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宁夏自然科学基金(2023AAC03319);教育部中西部高等学校青年骨干教师国内访问学者项目(2023)


Research advances in the bioactive secondary metabolites from lichen-derived actinomycetes
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    摘要:

    放线菌是许多具有生物活性特点新结构次级代谢物的重要来源。地衣是一种独特的菌藻共生体,其生态系统组成中除了形成地衣的真菌和藻类等外,还存在大量内生真菌和放线菌,这些内生菌因其独特的微生物次级代谢产物产生能力而引起了广泛的关注。研究地衣来源放线菌次级代谢产物对于新型活性先导化合物发现及药用微生物资源的开发利用等方面具有重要的意义。本文对近30年来从地衣来源内生放线菌中发现的次级代谢产物及其活性研究进行综述。

    Abstract:

    Actinomycetes are essential sources of secondary metabolites with diverse chemical structures and bioactivities. Lichen is a unique system of fungi and algae. In addition to lichenized fungi and algae, there are also a large number of endophytic fungi and actinomycetes in the lichen ecosystem, which have garnered increasing attention due to their unique ability to produce secondary metabolites. It is of great significance to study the secondary metabolites of lichen-derived actinomycetes for the discovery of active lead compounds and the development and utilization of medicinal microbial resources. This article reviews the research progress in the secondary metabolites and activities of lichen-derived actinomycetes in recent 30 years.

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马晓莉,田晶晶,丁范范,江志波. 地衣放线菌活性次级代谢产物研究进展[J]. 微生物学通报, 2025, 52(3): 931-947

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  • 收稿日期:2024-05-23
  • 录用日期:2024-06-07
  • 在线发布日期: 2025-03-19
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