肠道菌群调控脂质代谢作用与机制的研究进展

Advances in the role and mechanism of gut microbiota in regulating lipid metabolism

摘要:

近年来，肠道菌群对机体脂质代谢的调控机制成为研究热点。在肥胖小鼠或脂质代谢紊乱小鼠中，都存在肠道菌群的改变。通过粪菌移植、服用益生菌等方法可调节肠道菌群的平衡进而有效改善机体的脂质代谢紊乱。这篇综述中聚焦肠道菌群对脂质代谢的调控作用，并进一步从心血管系统疾病、神经系统疾病、非酒精性脂肪肝(non-alcoholic fatty liver disease, NAFLD)、肥胖和2型糖尿病(type 2 diabetes mellitus, T2DM)等脂质代谢紊乱疾病展开阐述，最后探索了肠道菌群调节脂质代谢紊乱的治疗前景。

关键词:肠道菌群;脂质代谢;肠道菌群代谢物

Abstract:

In recent years, the regulation mechanism of lipid metabolism by gut microbiota has become a focus of research. Changes in gut microbiota have been discovered in the mouse models of obesity and lipid metabolism disorders. Adjusting gut microbiota by fecal microbiota transplantation and probiotics can alleviate lipid metabolism disorders. This review focuses on the regulatory effect of gut microbiota on lipid metabolism and expounds the regulatory effects on cardiovascular diseases, nervous system diseases, non-alcoholic fatty liver disease, obesity, and type 2 diabetes mellitus. Finally, this paper explores the therapeutic prospects of regulating gut microbiota in the treatment of lipid metabolism disorders.

Key words:gut microbiota;lipid metabolism;gut microbiota-derived metabolites