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2025年4月26日 周六
首页 > 过刊浏览>2025年第52卷第1期 >46-59. DOI:10.13344/j.microbiol.china.240307
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后生元抗病毒性肠胃炎实验研究进展
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华南农业大学校企合作横向项目(H230386)


Experimental research progress in postbiotics against viral gastroenteritis
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    摘要:

    病毒性肠胃炎是由多种病毒引起的急性传染病。后生元可用于病毒性肠胃炎的预防和治疗，其具体临床可行性和治疗策略仍需进一步探究。本文详细介绍了国内外关于后生元组分抗轮状病毒、诺如病毒性肠胃炎及其作用机制的最新研究进展，分析后生元抗肠道病毒的研究现状及未来研究方向，有利于后生元在肠道病毒防治应用的研究。

    Abstract:

    Viral gastroenteritis is an acute infectious disease caused by multiple different viruses. Postbiotics can be used for the prevention and treatment of viral gastroenteritis, and the specific clinical feasibility and treatment strategy remain to be studied. This article reviews the latest research progress in the application and mechanism of postbiotic components in treating gastroenteritis caused by rotavirus and norovirus and discusses the current status and future research directions of postbiotics in inhibiting enteroviruses. This review is conducive to the research on the application of postbiotics in the prevention and treatment of enteroviruses.

    参考文献
    [1] CHIGOR VN, CHIDEBELU PE, DIGWO DC, CHIGOR CB, NWAGWU AU, UDEH OS, OGUONU CI, DIBUA ME U, FARKAS K. Assessment of the aetiology of acute gastroenteritis outbreaks in infants reveals rotavirus, noroviruses and adenovirus prevalence and viral coinfections in Nsukka, Nigeria[J]. Virus Disease, 2023, 34(2): 297-306.
    [2] OUDE MUNNINK BB, van der HOEK L. Viruses causing gastroenteritis: the known, the new and those beyond[J]. Viruses, 2016, 8(2): 42.
    [3] LEUNG AK, HON KL. Paediatrics: how to manage viral gastroenteritis[J]. Drugs in Context, 2021, 10: 2020-2011-7.
    [4] OZMA MA, ABBASI A, AKRAMI S, LAHOUTY M, SHAHBAZI N, GANBAROV K, PAGLIANO P, SABAHI S, KÖSE Ş, YOUSEFI M, DAO S, ASGHARZADEH M, HOSSEINI H, KAFIL HS. Postbiotics as the key mediators of the gut microbiota-host interactions[J]. Le Infezioni in Medicina, 2022, 30(2): 180-193.
    [5] HILL C, GUARNER F, REID G, GIBSON GR, MERENSTEIN DJ, POT B, MORELLI L, CANANI RB, FLINT HJ, SALMINEN S, CALDER PC, SANDERS ME. The international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic[J]. Nature Reviews Gastroenterology & Hepatology, 2014, 11: 506-514.
    [6] BUBNOV R, BABENKO L, LAZARENKO L, KRYVTSOVA M, SHCHERBAKOV O, ZHOLOBAK N, GOLUBNITSCHAJA O, SPIVAK M. Can tailored nanoceria act as a prebiotic? Report on improved lipid profile and gut microbiota in obese mice[J]. EPMA Journal, 2019, 10(4): 317-335.
    [7] HOJSAK I, FABIANO V, POP TL, GOULET O, ZUCCOTTI GV, ÇOKUĞRAŞ FC, PETTOELLO- MANTOVANI M, KOLAČEK S. Guidance on the use of probiotics in clinical practice in children with selected clinical conditions and in specific vulnerable groups[J]. Acta Paediatrica, 2018, 107(6): 927-937.
    [8] HOJSAK I, SZAJEWSKA H, CANANI RB, GUARINO A, INDRIO F, KOLACEK S, OREL R, SHAMIR R, VANDENPLAS Y, van GOUDOEVER JB. Probiotics for the prevention of nosocomial diarrhea in children[J]. Journal of Pediatric Gastroenterology and Nutrition, 2018, 66(1): 3-9.
    [9] SINDHU KNC, SOWMYANARAYANAN TV, PAUL A, BABJI S, AJJAMPUR SSR, PRIYADARSHINI S, SARKAR R, BALASUBRAMANIAN KA, WANKE CA, WARD HD, KANG G. Immune response and intestinal permeability in children with acute gastroenteritis treated with Lactobacillus rhamnosus GG: a randomized, double-blind, placebo-controlled trial[J]. Clinical Infectious Diseases, 2014, 58(8): 1107-1115.
    [10] VALLIANOU N, STRATIGOU T, CHRISTODOULATOS GS, TSIGALOU C, DALAMAGA M. Probiotics, prebiotics, synbiotics, postbiotics, and obesity: current evidence, controversies, and perspectives[J]. Current Obesity Reports, 2020, 9(3): 179-192.
    [11] LI YT, XU H, YE JZ, WU WR, SHI D, FANG DQ, LIU Y, LI LJ. Efficacy of Lactobacillus rhamnosus GG in treatment of acute pediatric diarrhea: a systematic review with meta-analysis[J]. World Journal of Gastroenterology, 2019, 25(33): 4999-5016.
    [12] WOMBWELL E, BRANSTEITTER B, GILLEN LR. Incidence of Saccharomyces cerevisiae fungemia in hospitalised patients administered Saccharomyces boulardii probiotic[J]. Mycoses, 2021, 64(12): 1521-1526.
    [13] APPEL-DA-SILVA MC, NARVAEZ GA, PEREZ LRR, DREHMER L, LEWGOY J. Saccharomyces cerevisiae var. boulardii fungemia following probiotic treatment[J]. Medical Mycology Case Reports, 2017, 18: 15-17.
    [14] GIBSON GR, HUTKINS R, SANDERS ME, PRESCOTT SL, REIMER RA, SALMINEN SJ, SCOTT K, STANTON C, SWANSON KS, CANI PD, VERBEKE K, REID G. Expert consensus document: the International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics[J]. Nature Reviews Gastroenterology & Hepatology, 2017, 14(8): 491-502.
    [15] HOEDT EC, HUESTON CM, CASH N, BONGERS RS, KEANE JM, van LIMPT K, BEN AMOR K, KNOL J, MacSHARRY J, van SINDEREN D. A synbiotic mixture of selected oligosaccharides and bifidobacteria assists murine gut microbiota restoration following antibiotic challenge[J]. Microbiome, 2023, 11(1): 168.
    [16] AZAGRA-BORONAT I, MASSOT-CLADERA M, KNIPPING K, VAN’T LAND B, STAHL B, GARSSEN J, RODRÍGUEZ-LAGUNAS MJ, FRANCH À, CASTELL M, PÉREZ-CANO FJ. Supplementation with 2'-FL and scGOS/lcFOS ameliorates rotavirus- induced diarrhea in suckling rats[J]. Frontiers in Cellular and Infection Microbiology, 2018, 8: 372.
    [17] AZAGRA-BORONAT I, MASSOT-CLADERA M, KNIPPING K, VAN’T LAND B, TIMS S, STAHL B, KNOL J, GARSSEN J, FRANCH À, CASTELL M, PÉREZ-CANO FJ, RODRÍGUEZ-LAGUNAS MJ. Oligosaccharides modulate rotavirus-associated dysbiosis and TLR gene expression in neonatal rats[J]. Cells, 2019, 8(8): 876.
    [18] JORGENSEN JM, YOUNG R, ASHORN P, ASHORN U, CHAIMA D, DAVIS JCC, GOONATILLEKE E, KUMWENDA C, LEBRILLA CB, MALETA K, SADALAKI J, TOTTEN SM, WU LD, ZIVKOVIC AM, DEWEY KG. Associations of human milk oligosaccharides and bioactive proteins with infant morbidity and inflammation in Malawian mother-infant dyads[J]. Current Developments in Nutrition, 2021, 5(5): nzab072.
    [19] MARTEAU P, SEKSIK P. Tolerance of probiotics and prebiotics[J]. Journal of Clinical Gastroenterology, 2004, 38(6 Suppl): S67-S69.
    [20] GORDON S. Elie Metchnikoff: father of natural immunity[J]. European Journal of Immunology, 2008, 38(12): 3257-3264.
    [21] 骆承庠. 酸乳制品及乳酸菌制剂[J]. 乳品工业, 1978, 6(2): 25-35, 39. LUO CX. Sour dairy products and lactic acid bacteria preparations[J]. China Dairy Industry, 1978, 6(2): 25-35, 39(in Chinese).
    [22] 周海泳, 宋军帅, 胡斌, 庞旭, 朱剑锋, 胡文锋. 乳猪料中添加灭活乳酸菌对早期断奶仔猪生长性能的影响[J]. 广东饲料, 2013, 22(1): 23-25. ZHOU HY, SONG JS, HU B, PANG X, ZHU JF, HU WF. Effect of adding inactivated lactic acid bacteria to suckling pig feed on growth performance of early weaned piglets[J]. Guangdong Feed, 2013, 22(1): 23-25(in Chinese).
    [23] 郑明英, 周海泳, 李适云, 胡文锋, 刘秉杰, 杨益衡, 陈永泉. 婴儿粪便中乳酸菌的分离鉴定及其对小鼠腹泻的治疗作用[J]. 现代食品科技, 2012, 28(7): 758-763, 767. ZHENG MY, ZHOU HY, LI SY, HU WF, LIU BJ, YANG YH, CHEN YQ. Isolation and identification of the lactic acid bacteria from infant faeces and their therapeutical effect on diarrhea of mice[J]. Modern Food Science and Technology, 2012, 28(7): 758-763, 767(in Chinese).
    [24] 胡文锋, 庞旭, 韩笑, 刘秉杰, 杨益衡. 一种灭活乳酸菌泡腾片及其制备方法: CN103211143B[P]. 2015-09-09. HU W, PANG X, HAN X, LIU B, YANG Y. Inactivated lactobacillus effervescent tablets and preparation method thereof: CN103211143B[P]. 2015-09-09(in Chinese).
    [25] 胡文锋, 黄艾武, 陈斌强, 于凌禹, 张明. 富锌灭活乳酸菌微生态制剂及其制备方法: CN101971921B[P]. 2013-05-08. HU W, HUANG A, CHEN B, YU L, ZHANG M. Zinc-enriched inactivated lactobacillus microecological agent and preparation method thereof: CN101971921B[P]. 2013-05-08(in Chinese).
    [26] 胡文锋, 毕英佐, 曹永长, 吴清平, 陈永泉. 灭活的乳酸菌微生态制剂及其制备方法: CN101612169B[P]. 2012-09-05. Hu WF, Bi YZ, Cao YC, Wu QP, Chen YQ. heat-killed microecological preparation of lactic acid bacteria and its preparation method: CN101612169B[P]. 2012-09-05(in Chinese).
    [27] 白尉伶, 郭宇晴, 叶靖怡, 黄美媛, 关慧银, 李雪玲. 唾液乳杆菌O2A及其所产抑菌物质应用于水产品防腐的研究[J]. 食品科技, 2017, 42(6): 2-6. BAI WL, GUO YQ, YE JY, HUANG MY, GUAN HY, LI XL. The fresh-keeping effect of Lactobacillus salivarius O2A on the aquatic products[J]. Food Science and Technology, 2017, 42(6): 2-6(in Chinese).
    [28] 李光月, 李雪玲, 祁姣姣, 韩明政, 朱剑锋, 胡学生, 胡文锋. 复合诱变对枯草芽孢杆菌表面活性素抗病毒能力的影响[J]. 黑龙江畜牧兽医, 2023(12): 119-124. LI GY, LI XL, QI JJ, HAN MZ, ZHU JF, HU XS, HU WF. Effects of compound mutagenesis on the antiviral activity of surfactin of Bacillus subtilis[J]. Heilongjiang Animal Science and Veterinary Medicine, 2023(12): 119-124(in Chinese).
    [29] SALMINEN S, COLLADO MC, ENDO A, HILL C, LEBEER S, QUIGLEY EMM, SANDERS ME, SHAMIR R, SWANN JR, SZAJEWSKA H, VINDEROLA G. The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics[J]. Nature Reviews Gastroenterology & Hepatology, 2021, 18(9): 649-667.
    [30] MANTZIARI A, SALMINEN S, SZAJEWSKA H, MALAGÓN-ROJAS JN. Postbiotics against pathogens commonly involved in pediatric infectious diseases[J]. Microorganisms, 2020, 8(10): 1510.
    [31] JI J, JIN WL, LIU SJ, JIAO ZY, LI XK. Probiotics, prebiotics, and postbiotics in health and disease[J]. MedComm, 2023, 4(6): e420.
    [32] BARRATT MJ, NUZHAT S, AHSAN K, FRESE SA, ARZAMASOV AA, SARKER SA, MUNIRUL ISLAM M, PALIT P, ISLAM MR, HIBBERD MC, NAKSHATRI S, COWARDIN CA, GURUGE JL, BYRNE AE, VENKATESH S, SUNDARESAN V, HENRICK B, DUAR RM, MITCHELL RD, CASABURI G, et al. Bifidobacterium infantis treatment promotes weight gain in Bangladeshi infants with severe acute malnutrition[J]. Science Translational Medicine, 2022, 14(640): eabk1107.
    [33] VINDEROLA G, SANDERS ME, SALMINEN S. The concept of postbiotics[J]. Foods, 2022, 11(8): 1077.
    [34] 谢莹莹, 庞旭, 周海泳, 徐健, 祁姣姣, 朱剑锋, 李雪玲, 杨美艳, 胡文锋. 后生元的作用机制及其在食品领域的应用[J]. 食品科学, 2024, 45(8): 354-363. XIE YY, PANG X, ZHOU HY, XU J, QI JJ, ZHU JF, LI XL, YANG MY, HU WF. Action mechanisms of postbiotics and their applications in food field[J]. Food Science, 2024, 45(8): 354-363(in Chinese).
    [35] ŻÓŁKIEWICZ J, MARZEC A, RUSZCZYŃSKI M, FELESZKO W. Postbiotics-a step beyond pre- and probiotics[J]. Nutrients, 2020, 12(8): 2189.
    [36] HERNÁNDEZ-GRANADOS MJ, FRANCO-ROBLES E. Postbiotics in human health: possible new functional ingredients?[J]. Food Research International, 2020, 137: 109660.
    [37] MALASHREE L, ANGADI V, YADAV KS, PRABHA R. “postbiotics”: one step ahead of probiotics[J]. International Journal of Current Microbiology and Applied Sciences, 2019, 8(1): 2049-2053.
    [38] SCARPELLINI E, RINNINELLA E, BASILICO M, COLOMIER E, RASETTI C, LARUSSA T, SANTORI P, ABENAVOLI L. From pre- and probiotics to post-biotics: a narrative review[J]. International Journal of Environmental Research and Public Health, 2021, 19(1): 37.
    [39] TEAME T, WANG AR, XIE MX, ZHANG Z, YANG YL, DING QW, GAO CC, OLSEN RE, RAN C, ZHOU ZG. Paraprobiotics and postbiotics of probiotic Lactobacilli, their positive effects on the host and action mechanisms: a review[J]. Frontiers in Nutrition, 2020, 7: 570344.
    [40] THORAKKATTU P, KHANASHYAM AC, SHAH K, BABU KS, MUNDANAT AS, DELIEPHAN A, DEOKAR GS, SANTIVARANGKNA C, NIRMAL NP. Postbiotics: current trends in food and pharmaceutical industry[J]. Foods, 2022, 11(19): 3094.
    [41] ROGGERO P, LIOTTO N, POZZI C, BRAGA D, TROISI J, MENIS C, GIANNÌ ML, BERNI CANANI R, PAPARO L, NOCERINO R, BUDELLI A, MOSCA F, RESCIGNO M. Analysis of immune, microbiota and metabolome maturation in infants in a clinical trial of Lactobacillus paracasei CBA L74-fermented formula[J]. Nature Communications, 2020, 11(1): 2703.
    [42] CORSELLO G, CARTA M, MARINELLO R, PICCA M, de MARCO G, MICILLO M, FERRARA D, VIGNERI P, CECERE G, FERRI P, ROGGERO P, BEDOGNI G, MOSCA F, PAPARO L, NOCERINO R, BERNI CANANI R. Preventive effect of cow’s milk fermented with Lactobacillus paracasei CBA L74 on common infectious diseases in children: a multicenter randomized controlled trial[J]. Nutrients, 2017, 9(7): 669.
    [43] NOCERINO R, PAPARO L, TERRIN G, PEZZELLA V, AMOROSO A, COSENZA L, CECERE G, de MARCO G, MICILLO M, ALBANO F, NUGNES R, FERRI P, CICCARELLI G, GIACCIO G, SPADARO R, MADDALENA Y, BERNI CANANI F, BERNI CANANI R. Cow’s milk and rice fermented with Lactobacillus paracasei CBA L74 prevent infectious diseases in children: a randomized controlled trial[J]. Clinical Nutrition, 2017, 36(1): 118-125.
    [44] SZAJEWSKA H, KOŁODZIEJ M, SKÓRKA A, PIEŚCIK-LECH M. Infant formulas with postbiotics: an updated systematic review[J]. Journal of Pediatric Gastroenterology and Nutrition, 2022, 74(6): 823-829.
    [45] HIDALGO-CANTABRANA C, DELGADO S, RUIZ L, RUAS-MADIEDO P, SÁNCHEZ B, MARGOLLES A. Bifidobacteria and their health-promoting effects[J]. Microbiology Spectrum, 2017. DOI: 10.1128/ microbiolspec.BAD-0010-2016.
    [46] GUARINO A, ASHKENAZI S, GENDREL D, LO VECCHIO A, SHAMIR R, SZAJEWSKA H. European society for pediatric gastroenterology, hepatology, and nutrition/European society for pediatric infectious diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe[J]. Journal of Pediatric Gastroenterology and Nutrition, 2014, 59(1): 132-152.
    [47] de PABLO N, MEANA C, MARTÍNEZ-GARCÍA J, MARTÍNEZ-VICENTE P, ALBERT M, GUERRA S, ANGULO A, BALSINDE J, BALBOA MA. Lipin-2 regulates the antiviral and anti-inflammatory responses to interferon[J]. EMBO Reports, 2023, 24(12): e57238.
    [48] NOLAN LS, BALDRIDGE MT. Advances in understanding interferon-mediated immune responses to enteric viruses in intestinal organoids[J]. Frontiers in Immunology, 2022, 13: 943334.
    [49] RIGO-ADROVER MDM, KNIPPING K, GARSSEN J, van LIMPT K, KNOL J, FRANCH À, CASTELL M, RODRÍGUEZ-LAGUNAS MJ, PÉREZ-CANO FJ. Prevention of rotavirus diarrhea in suckling rats by a specific fermented milk concentrate with prebiotic mixture[J]. Nutrients, 2019, 11(1): 189.
    [50] LEE W, KIM M, LEE SH, JUNG HG, OH JW. Prophylactic efficacy of orally administered Bacillus poly-γ-glutamic acid, a non-LPS TLR4 ligand, against norovirus infection in mice[J]. Scientific Reports, 2018, 8(1): 8667.
    [51] VANCAMELBEKE M, VERMEIRE S. The intestinal barrier: a fundamental role in health and disease[J]. Expert Review of Gastroenterology & Hepatology, 2017, 11(9): 821-834.
    [52] 张中伟, 秦环龙. 肠上皮细胞紧密连接的结构及功能研究进展[J]. 肠外与肠内营养, 2005, 12(6): 367-369, 381. ZHANG ZW, QIN HL. The study of the molecular structure and function of intestinal epithelial tight junction proteins[J]. Parenteral & Enteral Nutrition, 2005, 12(6): 367-369, 381(in Chinese).
    [53] BRUNO C, PAPARO L, PISAPIA L, ROMANO A, CORTESE M, PUNZO E, BERNI CANANI R. Protective effects of the postbiotic deriving from cow’s milk fermentation with L. paracasei CBA L74 against Rotavirus infection in human enterocytes[J]. Scientific Reports, 2022, 12(1): 6268.
    [54] PAPARO L, AITORO R, NOCERINO R, FIERRO C, BRUNO C, CANANI RB. Direct effects of fermented cow’s milk product with Lactobacillus paracasei CBA L74 on human enterocytes[J]. Beneficial Microbes, 2018, 9(1): 165-172.
    [55] MARTÍNEZ-RUIZ S, OLIVO-MARTÍNEZ Y, CORDERO C, RODRÍGUEZ-LAGUNAS MJ, PÉREZ-CANO FJ, BADIA J, BALDOMA L. Microbiota-derived extracellular vesicles as a postbiotic strategy to alleviate diarrhea and enhance immunity in rotavirus-infected neonatal rats[J]. International Journal of Molecular Sciences, 2024, 25(2): 1184.
    [56] BHAR S, ZHAO GQ, BARTEL JD, STERCHELE H, del MAZO A, EMERSON LE, EDELMANN MJ, JONES MK. Bacterial extracellular vesicles control murine norovirus infection through modulation of antiviral immune responses[J]. Frontiers in Immunology, 2022, 13: 909949.
    [57] KIM K, LEE G, THANH HD, KIM JH, KONKIT M, YOON S, PARK M, YANG S, PARK E, KIM W. Exopolysaccharide from Lactobacillus plantarum LRCC5310 offers protection against rotavirus-induced diarrhea and regulates inflammatory response[J]. Journal of Dairy Science, 2018, 101(7): 5702-5712.
    [58] BUCCIGROSSI V, POETA M, CIOFFI V, TERRANOVA S, NUNZIATA F, VECCHIO AL, GUARINO A. Lacticaseibacillus rhamnosus GG counteracts rotavirus-induced ion secretion and enterocyte damage by inhibiting oxidative stress and apoptosis through specific effects of living and postbiotic preparations[J]. Frontiers in Cellular and Infection Microbiology, 2022, 12: 854989.
    [59] BUCCIGROSSI V, LAUDIERO G, RUSSO C, MIELE E, SOFIA M, MONINI M, RUGGERI FM, GUARINO A. Chloride secretion induced by rotavirus is oxidative stress-dependent and inhibited by Saccharomyces boulardii in human enterocytes[J]. PLoS One, 2014, 9(6): e99830.
    [60] POETA M, CIOFFI V, TARALLO A, DAMIANO C, VECCHIO AL, BRUZZESE E, PARENTI G, GUARINO A. Postbiotic preparation of Lacticaseibacillus rhamnosus GG against diarrhea and oxidative stress induced by spike protein of SARS-CoV-2 in human enterocytes[J]. Antioxidants, 2023, 12(10): 1878.
    [61] ABOUBAKR HA, EL-BANNA AA, YOUSSEF MM, AL-SOHAIMY SAA, GOYAL SM. Antiviral effects of Lactococcus lactis on feline calicivirus, A human norovirus surrogate[J]. Food and Environmental Virology, 2014, 6(4): 282-289.
    [62] BERNI CANANI R, de FILIPPIS F, NOCERINO R, LAIOLA M, PAPARO L, CALIGNANO A, de CARO C, CORETTI L, CHIARIOTTI L, GILBERT JA, ERCOLINI D. Specific signatures of the gut microbiota and increased levels of butyrate in children treated with fermented cow’s milk containing heat-killed Lactobacillus paracasei CBA L74[J]. Applied and Environmental Microbiology, 2017, 83(19): e01206-17.
    [63] SUNMOLA AA, OGBOLE OO, FALEYE TOC, ADETOYE A, ADENIJI JA, AYENI FA. Antiviral potentials of Lactobacillus plantarum, Lactobacillus amylovorus, and Enterococcus hirae against selected Enterovirus[J]. Folia Microbiologica, 2019, 64(2): 257-264.
    [64] OMATOLA CA, OLANIRAN AO. Rotaviruses: from pathogenesis to disease control-a critical review[J]. Viruses, 2022, 14(5): 875.
    [65] AMIMO JO, RAEV SA, CHEPNGENO J, MAINGA AO, GUO YS, SAIF L, VLASOVA AN. Rotavirus interactions with host intestinal epithelial cells[J]. Frontiers in Immunology, 2021, 12: 793841.
    [66] SIMAKACHORN N, PICHAIPAT V, RITHIPORNPAISARN P, KONGKAEW C, TONGPRADIT P, VARAVITHYA W. Clinical evaluation of the addition of lyophilized, heat-killed Lactobacillus acidophilus LB to oral rehydration therapy in the treatment of acute diarrhea in children[J]. Journal of Pediatric Gastroenterology and Nutrition, 2000, 30(1): 68-72.
    [67] SZAJEWSKA H, RUSZCZYŃSKI M, KOLAČEK S. Meta-analysis shows limited evidence for using Lactobacillus acidophilus LB to treat acute gastroenteritis in children[J]. Acta Paediatrica, 2014, 103(3): 249-255.
    [68] SALAS-CÁRDENAS SP, OLAYA-GALÁN NN, FERNÁNDEZ K, VELEZ F, GUERRERO CA, GUITIÉRREZ MF. Decreased rotavirus infection of MA104 cells via probiotic extract binding to Hsc70 and ß3 integrin receptors[J]. Universitas Scientiarum, 2018, 23(2): 219-239.
    [69] CHENOLL E, CASINOS B, BATALLER E, BUESA J, RAMÓN D, GENOVÉS S, FÁBREGA J, RIVERO URGELL M, MORENO MUÑOZ JA. Identification of a peptide produced by Bifidobacterium longum CECT 7210 with antirotaviral activity[J]. Frontiers in Microbiology, 2016, 7: 655.
    [70] OLAYA GALÁN NN, ULLOA RUBIANO JC, VELEZ REYES FA, FERNANDEZ DUARTE KP, SALAS CÁRDENAS SP, GUTIERREZ FERNANDEZ MF. In vitro antiviral activity of Lactobacillus casei and Bifidobacterium adolescentis against rotavirus infection monitored by NSP4 protein production[J]. Journal of Applied Microbiology, 2016, 120(4): 1041-1051.
    [71] THIBAULT H, AUBERT-JACQUIN C, GOULET O. Effects of long-term consumption of a fermented infant formula (with Bifidobacterium breve c50 and Streptococcus thermophilus 065) on acute diarrhea in healthy infants[J]. Journal of Pediatric Gastroenterology and Nutrition, 2004, 39(2): 147-152.
    [72] RIGO-ADROVER M, PÉREZ-BEREZO T, RAMOS- ROMERO S, van LIMPT K, KNIPPING K, GARSSEN J, KNOL J, FRANCH À, CASTELL M, PÉREZ-CANO FJ. A fermented milk concentrate and a combination of short-chain galacto-oligosaccharides/long-chain fructo- oligosaccharides/pectin-derived acidic oligosaccharides protect suckling rats from rotavirus gastroenteritis[J]. British Journal of Nutrition, 2017, 117(2): 209-217.
    [73] MORALES-FERRÉ C, AZAGRA-BORONAT I, MASSOT-CLADERA M, TIMS S, KNIPPING K, GARSSEN J, KNOL J, FRANCH À, CASTELL M, PÉREZ-CANO FJ, RODRÍGUEZ-LAGUNAS MJ. Preventive effect of a postbiotic and prebiotic mixture in a rat model of early life rotavirus induced-diarrhea[J]. Nutrients, 2022, 14(6): 1163.
    [74] HYSER JM, COLLINSON-PAUTZ MR, UTAMA B, ESTES MK. Rotavirus disrupts calcium homeostasis by NSP4 viroporin activity[J]. mBio, 2010, 1(5): e00265-10.
    [75] CRAWFORD SE, RAMANI S, TATE JE, PARASHAR UD, SVENSSON L, HAGBOM M, FRANCO MA, GREENBERG HB, O’RYAN M, KANG G, DESSELBERGER U, ESTES MK. Rotavirus infection[J]. Nature Reviews Disease Primers, 2017, 3(1): 17083.
    [76] BIALOWAS S, HAGBOM M, NORDGREN J, KARLSSON T, SHARMA S, MAGNUSSON KE, SVENSSON L. Rotavirus and serotonin cross-talk in diarrhoea[J]. PLoS One, 2016, 11(7): e0159660.
    [77] FERNANDEZ-DUARTE KP, OLAYA-GALÁN NN, SALAS-CÁRDENAS SP, LOPEZ-ROZO J, GUTIERREZ-FERNANDEZ MF. Bifidobacterium adolescentis (DSM 20083) and Lactobacillus casei (lafti L26-DSL): probiotics able to block the in vitro adherence of rotavirus in MA104 cells[J]. Probiotics and Antimicrobial Proteins, 2018, 10(1): 56-63.
    [78] HERNÁNDEZ M, SIEGER M, BARRETO A, GUERRERO CA, ULLOA J. Postbiotic activities of Bifidobacterium adolescentis: impacts on viability, structural integrity, and cell death markers in human intestinal C2BBe1 cells[J]. Pathogens, 2023, 13(1): 17.
    [79] HAN YO, JEONG Y, YOU HJ, KU S, JI GE, PARK MS. The anti-rotaviral activity of low molecular weight and non-proteinaceous substance from Bifidobacterium longum BORI cell extract[J]. Microorganisms, 2019, 7(4): 108.
    [80] RIGO-ADROVER M, SALDAÑA-RUÍZ S, van LIMPT K, KNIPPING K, GARSSEN J, KNOL J, FRANCH A, CASTELL M, PÉREZ-CANO FJ. A combination of scGOS/lcFOS with Bifidobacterium breve M-16V protects suckling rats from rotavirus gastroenteritis[J]. European Journal of Nutrition, 2017, 56(4): 1657-1670.
    [81] ROMOND MB, AIS A, GUILLEMOT F, BOUNOUADER R, CORTOT A, ROMOND C. Cell-free whey from milk fermented with Bifidobacterium breve C50 used to modify the colonic microflora of healthy subjects[J]. Journal of Dairy Science, 1998, 81(5): 1229-1235.
    [82] DÍAZ-GARRIDO N, BADIA J, BALDOMÀ L. Microbiota-derived extracellular vesicles in inter Kingdom communication in the gut[J]. Journal of Extracellular Vesicles, 2021, 10(13): e12161.
    [83] HASSAN E, BALDRIDGE MT. Norovirus encounters in the gut: multifaceted interactions and disease outcomes[J]. Mucosal Immunology, 2019, 12(6): 1259-1267.
    [84] de GRAAF M, van BEEK J, KOOPMANS MPG. Human norovirus transmission and evolution in a changing world[J]. Nature Reviews Microbiology, 2016, 14(7): 421-433.
    [85] 曹颖雯, 杜青瑶, 徐锐权, 洪晓静, 寇晓霞. 乳酸杆菌后生元体外抗诺如病毒感染的作用及机制初探[J]. 现代预防医学, 2023, 50(4): 705-710. CAO YW, DU QY, XU RQ, HONG XJ, KOU XX. Against norovirus infection effects and preliminary mechanisms of action of postbiotics derived from probiotic Lactobacillus in vitro[J]. Modern Preventive Medicine, 2023, 50(4): 705-710(in Chinese).
    [86] SEO DJ, JUNG D, JUNG S, YEO D, CHOI C. Inhibitory effect of lactic acid bacteria isolated from kimchi against murine norovirus[J]. Food Control, 2020, 109: 106881.
    [87] LI Y, GAO JS, XUE L, SHANG YY, CAI WC, XIE XQ, JIANG T, CHEN HZ, ZHANG JM, WANG J, CHEN MT, DING Y, WU QP. Determination of antiviral mechanism of centenarian gut-derived Limosilactobacillus fermentum against norovirus[J]. Frontiers in Nutrition, 2022, 9: 812623.
    [88] GRAU KR, ZHU S, PETERSON ST, HELM EW, PHILIP D, PHILLIPS M, HERNANDEZ A, TURULA H, FRASSE P, GRAZIANO VR, WILEN CB, WOBUS CE, BALDRIDGE MT, KARST SM. The intestinal regionalization of acute norovirus infection is regulated by the microbiota via bile acid-mediated priming of type III interferon[J]. Nature Microbiology, 2020, 5(1): 84-92.
    [89] TIAN JD, MIDDLETON B, KAUFMAN DL. GABAA-receptor agonists limit pneumonitis and death in murine coronavirus-infected mice[J]. Viruses, 2021, 13(6): 966.
    [90] CAVICCHIOLI VQ, de CARVALHO OV, de PAIVA JC, TODOROV SD, SILVA A Jr, NERO LA. Inhibition of herpes simplex virus 1(HSV-1) and poliovirus (PV-1) by bacteriocins from Lactococcus lactis subsp. lactis and Enterococcus durans strains isolated from goat milk[J]. International Journal of Antimicrobial Agents, 2018, 51(1): 33-37.
    [91] PAPARO L, BRUNO C, FERRUCCI V, PUNTO E, VISCARDI M, FUSCO G, CERINO P, ROMANO A, ZOLLO M, BERNI CANANI R. Protective effects elicited by cow milk fermented with L. Paracasei CBA L74 against SARS-CoV-2 infection in human enterocytes[J]. Journal of Functional Foods, 2021, 87: 104787.
    [92] de VRESE M, RAUTENBERG P, LAUE C, KOOPMANS M, HERREMANS T, SCHREZENMEIR J. Probiotic bacteria stimulate virus-specific neutralizing antibodies following a booster polio vaccination[J]. European Journal of Nutrition, 2005, 44(7): 406-413.
    [93] CHEN MF, WENG KF, HUANG SY, LIU YC, TSENG SN, OJCIUS DM, SHIH SR. Pretreatment with a heat-killed probiotic modulates monocyte chemoattractant protein-1 and reduces the pathogenicity of influenza and enterovirus 71 infections[J]. Mucosal Immunology, 2017, 10(1): 215-227.
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凌健棉,王盼,黎金彩,蔡赐美,周海泳,晏琦,胡文锋,李雪玲. 后生元抗病毒性肠胃炎实验研究进展[J]. 微生物学通报, 2025, 52(1): 46-59

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  • 收稿日期:2024-04-17
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