乳酸菌对抑郁症的影响及其可能的作用机制

Amelioration of depression by lactic acid bacteria and its possible mechanism of action

摘要:

抑郁症是一种常见的精神疾病，其发病率逐年上升。近年来，使用乳酸菌治疗抑郁症得到了关注，越来越多的动物和人体研究证明了乳酸菌的抗抑郁功效。研究表明，乳酸菌可以缓解由抑郁症引起的肠道菌群失衡，进而改善宿主的行为和情绪。本文总结了乳酸菌对抑郁症的影响及其可能的作用机制，以及抗抑郁乳酸菌的分离来源，旨在为乳酸菌抗抑郁的研究提供新见解。

关键词:抑郁症;乳酸菌;肠道菌群;研究进展

Abstract:

Depression is a prevalent mental health disorder with rising incidence annually. In recent years, the application of lactic acid bacteria as a therapy for depression has garnered great attention. A growing body of animal and human studies has confirmed the antidepressive efficacy of lactic acid bacteria. Studies have revealed that lactic acid bacteria can mitigate the intestinal flora imbalance induced by depression, thereby modulating the behaviors and moods of the host. This review summarized the effects and mechanisms of lactic acid bacteria on depression and discusses the sources of lactic acid bacteria isolated for treating depression, aiming to offer novel perspectives for research on the antidepressive properties of lactic acid bacteria.

Key words:depression;lactic acid bacteria;intestinal flora;research progress