Abstract:Plants are subjected to biotic and abiotic stresses during growth, of which pathogen infection is a major biotic stress. Since the plant microbiome co-evolves with plants, the plants exposed to pathogen stress will fight against pathogens by special secretions or recruitment of beneficial microorganisms. This paper reviews the research progress in the “cry for help” strategy of plants under pathogen stress from the changes in plant microbiome and metabolites, plant-microbe interactions, the disease-suppressive soil formed after the plant “cry for help”, with a view to providing a basis for the prevention and control of soil-borne diseases in plants.