MicroRNA调控猪繁殖与呼吸综合征病毒复制机制的研究进展

Research progress in the mechanisms of microRNA-mediated regulation of porcine reproductive and respiratory syndrome virus replication

摘要:

猪繁殖与呼吸综合征(porcine reproductive and respiratory syndrome, PRRS)作为生猪养殖业的重要传染病，严重威胁着全球生猪养殖的健康发展。宿主微小RNA (microRNA, miRNA)是一类宿主内源性表达的非编码单链小RNA，通过与特定靶基因结合，影响宿主细胞发育、代谢凋亡、免疫反应等多种生命进程。目前多项研究表明miRNA可通过直接作用和间接作用参与调控病毒感染和复制的过程，本文就miRNA对猪繁殖与呼吸综合征病毒(porcine reproductive and respiratory syndrome virus, PRRSV)感染期间在调控病毒复制和宿主先天免疫反应的分子机制进行综述，旨在为miRNA的开发应用和PRRS的防治提供参考。

Abstract:

Porcine reproductive and respiratory syndrome (PRRS) is a major infectious disease in the swine industry, posing a severe threat to global pig farming. Host microRNAs (miRNAs) are endogenous small non-coding single-stranded RNAs that regulate various biological processes, including cell development, metabolism, apoptosis, and immune responses, by binding to specific target genes. Studies have demonstrated that miRNAs participate in the regulation of viral infection and replication through both direct and indirect mechanisms. This review focuses on the molecular mechanisms by which miRNAs modulate porcine reproductive and respiratory syndrome virus (PRRSV) replication and host innate immune responses during infection, aiming to provide insights for the development of miRNA-based applications and strategies for PRRS control.